Author

Kun Li

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Review Open access Sep 2026

Multi-kingdom microbial diversity and interaction landscapes in mosquitoes revealed by 5,163 individual meta-transcriptomes

Mosquitoes are pathogen vectors embedded within diverse microbial ecosystems. However, the nature and interactions among their multi-kingdom microbiome remain poorly understood. We conducted a nationwide single-mosquito meta-transcriptomic survey of 5,163 mosquitoes representing 100 species across China, integrating vi...

Qin-yu Gou, Wei-Chen Wu, Pei-Bo Shi et al. · bioRxiv · 0 citations

Open access Aug 2026

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that regulates diverse cellular responses, including antiviral immunity, through its conjugation to proteins in a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the...

Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al. · Immunity · 0 citations