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Review Open access Sep 2026

HDAC inhibitors in cancer therapy: sensitization mechanisms, combination strategies, and translational challenges

Histone deacetylases (HDACs) are key regulators of chromatin architecture and gene expression, and their dysregulation is closely linked to tumorigenesis, making them attractive targets for cancer therapy. Histone deacetylase inhibitors (HDACis) exert broad antitumor effects by modulating both epigenetic and non-epigen...

Kun Liu, Xiang Zhao, Jia-Hui Liu et al. · 0 citations
Review Open access Sep 2026

When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease

Lactate accumulation occurs in diverse physiological and pathological states, including hypoxia, ischemia, development, wound healing, immune activation, and cancer, where it functions as a key regulator of cellular energy metabolism, signal transduction, microenvironmental homeostasis, and immune responses. Protein la...

Xiang Zhao, Jia-Hui Liu, Kun Liu et al. · 0 citations

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