Aug 2026
A novel peptide encoded by circTLL1 drives osimertinib resistance in lung cancer by modulating the NT5C2/Ras/PI3K axis.
The identification of the circTLL1-90aa/NT5C2/Ras/PI3K axis not only expands the functional repertoire of the non-coding genome but also provides new insights into the complexity of drug resistance.
Miao He, Kun-peng Li, Wan-Xia Yang et al.
· Cellular Signalling · 0 citations