Hemiplegia, as a common sequela of stroke, can severely affect patients’ quality of life. Although rehabilitation therapy can improve neurological function and motor abilities, a single therapy often has limited effectiveness in meeting the comprehensive rehabilitation needs. Clinical observations have demonstrated...
Hong-Liang Wang, Xiao-Yan Tang, Pei-Zhe Li et al.· Frontiers in Neurology· 0 citations
Visceral hypersensitivity is a hallmark pathophysiological feature of irritable bowel syndrome, characterized by enhanced perception of visceral stimuli and a reduced pain threshold. Although previous studies have mainly attributed visceral hypersensitivity to peripheral inflammation, visceral afferent sensitization, a...
Yu Wang, Pei-Zhe Li, Ya-Nan Dong et al.· Frontiers in Immunology· 0 citations
A narrative review elaborates the molecular regulatory mechanisms of the PINK1/PARKIN pathway and proposes a tentative pathological cascade: impaired PINK1/PARKIN signaling – defective mitophagy – gastrointestinal dysmotility, visceral hypersensitivity and chronic low-grade inflammation – FD onset and progression.
Pei-Zhe Li, Yu Wang, Ya-Nan Dong et al.· Frontiers in Physiology· 0 citations
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