Kylie A. Agnew-Francis

Squaramide-functionalised amino acids and their application in solid-phase peptide synthesis

Squaramides are well-known charge-neutral bioisosteres of many nitrogenous functional groups, including those found in the side chains of amino acids (e.g., Arg, Asn, Glu, and Lys). However, there are very few reports of squaramide-functionalisation of these side chains. Herein, we report a convenient three-step synthe...