Open access
Sep 2026
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying metabolic signals involved remain unclear. Using a mouse model of mitohormesis, we show that transient mitochondrial superox...
Matthew P. Donnelly, K. Mangalhara, Yue-Ning Liu et al.
· Science Advances · 0 citations