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Author

Kyong-Mi Chang

2 papers indexed here

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Open access Sep 2026

Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways

Background Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applications. We leveraged the VA Million Veteran P...

Shuai Yuan, Michael G. Clark, G. Shakt et al. · 0 citations
Open access Sep 2026

Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease

Background: Thoracic aortic aneurysms enlarge silently and can cause fatal aortic dissection without timely surgical repair, underscoring the need for improved approaches to identify individuals at high risk. Rare pathogenic variants in established heritable thoracic aortic disease (HTAD) genes explain only a subset of...

David R. Murdock, Pu-Jun Guan, Dong-Chuan Guo et al. · 0 citations

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