Association of solute carrier family 19 member 1 (SLC19A1) A80G polymorphism with the maternal risk for having a child with Down syndrome: A systematic review and meta-analysis.
Impairments in folate metabolism have long been suspected to contribute to chromosome 21 aneuploidy and Down syndrome (DS). Indeed, several studies have investigated the role of a functional polymorphism in the reduced folate carrier gene, known as either SLC19A1 or RFC-1 A80G polymorphism (rs1051266), as a maternal ri...