Author

L. Balasse

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Open access Sep 2026

A novel 5-FU derivative chemotherapy: a promising pan-cancer treatment to improve antitumor efficacy and overcome therapy resistance

Mechanistically, EB-18 exerts multifaceted antitumor effects by disrupting the HSP27/DDX5 axis and DNA damage-response machinery, promoting DNA damage and apoptosis, while suppressing AKT/mTOR prosurvival signaling.

Quang Hieu Duong, E. Khusnutdinova, T. Le et al. · Journal of Experimental &amp... · 0 citations