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L. Bigelow

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Open access Sep 2026

Design and Exploration of a Tricyclic Series of CNS-Penetrant CD38 Small Molecule Inhibitors

Cluster of Differentiation 38 (CD38) plays a key role in NAD+ metabolism and calcium signaling, and recent reports highlight therapeutic opportunities for CD38 modulation in central nervous system (CNS) disorders. In this report, we describe the rational design, synthesis, and exploration of structure–activity relati...

Timothy R. Hodges, Youngjin Jang, Katerina M. Korch et al. · 0 citations

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