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Author

Lauren R. Brinster

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Open access Sep 2026

Rescue of Proteus syndrome lethality in mice with prenatal miransertib treatment.

PURPOSE Proteus syndrome is caused by constitutive AKT1 activation, resulting in severe overgrowth and tumor susceptibility. We developed a mouse model, featuring endogenously regulated, mosaic expression of the Akt1 c.49G>A, p.(Glu17Lys) (Akt1 E17K) variant. Prior results showed that ubiquitous Akt1E17K expression cau...

Shaima Raji Abdul Rahiman Sirajuddeen, M. Lindhurst, Megan Detels et al. · 0 citations
Open access Jul 2026

A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response 2308711

A systematic catalog of eRNAs in human adaptive immune cells is defined and a distal transcribed enhancer is identified that fine-tunes KRAS signaling in Tfh cells to support effective vaccine responses, establishing eRNAs as noncoding regulators of T cell circuits controlling antibody production.

Dhaneshwar Kumar, S. Sahoo, B. Yan et al. · 0 citations

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