Oct 2026
Programming CRISPR Compartmentalization on DNA Origami for Multiplexed Biosensing
CRISPR-Cas12a has emerged as a transformative tool for nucleic acid detection and molecular diagnostics. However, achieving one-pot, orthogonal, multiplexed sensing remains challenging due to the nonspecific trans-cleavage activity of Cas12a. Here, we present a modular DNA origami-based platform that spatially confin...
L. Capelli, Ya-Ya Hao, Qien Shi et al.
· Analytical Chemistry · 0 citations