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Open access Oct 2026

The diagnostic journey of fibrodysplasia ossificans progressiva: evidence from a national cohort of 114 patients

A cross-sectional analysis of 114 patients with molecularly confirmed FOP enrolled in the National Rare Diseases Registry System of China provides a rationale for prospective evaluation of an early-recognition pathway emphasizing examination of the great toes, avoidance of invasive procedures when FOP is suspected, ACV...

L. Cui, Quan-Shi Ouyang, Jian Guo et al. · 0 citations
Open access Oct 2026

Impact of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk: real-world evidence from a retrospective cohort study.

Bisphosphonate drug holidays can reduce rare adverse effects, but their skeletal impact is unclear. In this retrospective cohort study, ALN holiday caused modest BMD loss and BTMs rise without increased fracture risk; effects of ZOL holiday were minimal. This study suggests bisphosphonate drug holidays are safe for sel...

Shu-Quan Zhang, Zhi-Xiang Wang, Ruo-Tong Zhou et al. · 0 citations
Open access Aug 2026

Machine learning-based screening model for osteoporosis in Chinese postmenopausal women: a nationwide study with prospective fracture validation.

This study develops a machine learning model to predict osteoporosis in Chinese postmenopausal women. The model was trained using the largest nationwide cohort and externally validated. It showed AUCs of 0.744-0.798 and demonstrated prognostic value for 5-year fracture risk, supporting population-level screening where...

Qichao Sun, Xiang-Jun Yin, Wei-zhong Yu et al. · 0 citations

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