Author

L. D. de Graaff

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Open access Oct 2026

Testosterone Replacement Therapy in Adolescents and Young Adults With Prader-Willi Syndrome: Efficacy and Effects on Behaviour.

CONTEXT Hypogonadism in Prader-Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre-existing challenging behaviour in male patients with PWS. OBJECTIVE To inve...

Wiebe R. Flamman, Demi J. Trueba-Timmermans, L. Grootjen et al. · Clinical Endocrinology · 0 citations

Case report Open access Aug 2026

Case Report: A novel HNRNPK gene variant causing Au-Kline syndrome; the genotype and phenotype of the oldest individual ever described

This case underscores that the genetic and neuropsychological identification of a neurodevelopmental disorder, together with the integration of tailored psychomotor interventions and contextual adaptations, can improve psychiatric management and daily functioning, and mitigate behavioral decline in adulthood, even foll...

A. Bos-Roubos, Rosalie Te Brinke, A. Kattentidt-Mouravieva et al. · Frontiers in Psychiatry · 0 citations