Author

L. Depestel

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Open access Oct 2026

Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma.

High-risk neuroblastoma remains a leading cause of pediatric cancer mortality, underscoring the need for novel therapeutics. MYCN amplification drives transcriptional addiction, creating vulnerabilities for therapeutic intervention. Inhibition of CDK12, a key regulator of transcription elongation, downregulates DNA dam...

J. Goulding, Stijn T. Couwenbergh, Sarah-Lee Bekaert et al. · Cell Reports · 0 citations

Review Open access Aug 2026

A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability.

Neuroblastoma is characterised by extensive genomic instability despite a marked paucity of recurrent somatic mutations. Instead, the disease is predominantly driven by chromosomal alterations, including segmental chromosomal imbalances, small structural variants, and oncogene amplification. A major unmet challenge is...

E. Hilgert, L. Depestel, N. Van Roy et al. · British Journal of Cancer · 0 citations