Author

L. Downie

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Open access Sep 2026

The effect of 0.1% topical ciclosporin a for 12-weeks on the ocular surface innate and adaptive immune response in dry eye disease: protocol for a randomized controlled clinical trial

Abstract Background Ocular surface immune cells and pro-inflammatory cytokines have been reported to be increased in Dry eye disease (DED). Immunosuppressive agents such as topical cyclosporine A (CsA) can inhibit dendritic cell and T cell activation. However, CsA’s impact on ocular surface immune responses and tear cy...

Soumen Sadhu, Isabelle Jalbert, Meng-Liang Wu et al. · Annals medicus · 0 citations

Open access Jul 2026

Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sex

Human and murine data support a model in which systemic immune history, age and biological sex influence local immune surveillance at the human ocular surface, and identify CXCR6 as required for efficient T cell recruitment to the cornea of viral-infected mice.

Meng-Liang Wu, Sarah C. Monard, Marina H. Yakou et al. · bioRxiv · 0 citations