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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

L. Eriksson

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Open access Aug 2026

Targeting Insulin Signaling and TRAF2/JNK Pathway: A Comprehensive In Silico Study of Uncaria tomentosa Compounds

Investigation of mechanisms of action of 14 compounds from Uncaria tomentosa, a medicinal plant from the Amazon rainforest, using in silico modeling suggests that specific UT compounds may be used in experimental tests to investigate their therapeutic potential in managing T2D by modulating signaling pathways related t...

Bruna Freitas Marchi, Shraddha Parate, V. Jha et al. · 0 citations
Open access Jul 2026

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules designed to induce targeted protein degradation by forming a transient ternary complex between an E3 ubiquitin ligase and a protein of interest (POI), leading to the E3‐mediated ubiquitination of the POI and its subsequent proteasomal degradation. Alth...

Sébastien Sueron, S. J. Mahdizadeh, Eric Chevet et al. · 0 citations

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