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Author

L. Esteban-Martínez

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Sep 2026

Calpain-Dependent Protein Degradation Contributes to CASQ2-R33Q CPVT.

Couplon protein loss in CPVT associated with CASQ2-R33Q is mediated by coordinated but distinct proteolytic pathways, with calpain-dependent TRDN degradation representing a key pathogenic event that promotes CASQ2 destabilization and arrhythmogenesis.

Laura Ramos-Hernández, D. J. Santiago, Rocío F. Serrano-Blanco et al. · 0 citations

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