Azithromycin-resistant Salmonella enterica Typhi with AcrB R717L/Q mutations in the United States.
Background and objectives Azithromycin is a critical oral treatment for typhoid fever caused by Salmonella enterica serovar Typhi (Salmonella Typhi), since XDR has rendered other first-line treatment options ineffective. Azithromycin resistance conferred by amino acid changes in AcrB, an AcrAB-TolC efflux pump componen...