MCH-02, a synthetic macamide analog with in vitro FAAH-inhibitory activity, modulates hippocampal endocannabinoid system and BK channel expression without preventing PTZ-induced progressive seizure susceptibility in rats
Epilepsy remains a major neurological disorder, with about 30% of patients showing drug resistance despite the availability of multiple antiseizure medications. The endocannabinoid system (ECS) has emerged as a promising therapeutic target due to its role in regulating neuronal excitability. This study examined the e...