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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

L. Farrer

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3 papers indexed here

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Open access Aug 2026

A multiancestry polygenic risk score for Alzheimer’s disease is associated with cognitive decline and neuropathological hallmarks in diverse populations

Previously derived polygenic risk scores (PRSs) for Alzheimer’s disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ancestry, African American, Caribbean Hispanic and East Asian co...

N. Kurniansyah, S. Tasaki, H. Rehman et al. · 0 citations
Open access Aug 2026

Context-dependent regulatory networks connect Alzheimer’s disease genetics to microglial inflammatory responses

Inflammation is central to Alzheimer’s disease (AD) pathogenesis. Microglia, the resident innate immune cells of the brain, exhibit diverse inflammatory states and are enriched for AD-associated genetic variants within active cis-regulatory elements (CREs). However, the interplay among genetic variants, transcription f...

Ting-Ting Fu, Margareta Kurkela, Jia-Yong Tu et al. · 0 citations

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