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Open access Oct 2026

Definitive radiotherapy versus surgery after neoadjuvant immunochemotherapy for locally advanced esophageal squamous cell carcinoma: a propensity score-matched study of efficacy and safety

The optimal local treatment strategy for locally advanced esophageal squamous cell carcinoma (LA-ESCC) following neoadjuvant immunochemotherapy (NICT) remains controversial. This study aimed to compare the survival outcomes and recurrence patterns of radical surgery and definitive radiotherapy (RT) following NICT i...

Qiu-Ying An, Ya-Ge Jia, Meng-Lu Liu et al. · 0 citations
Sep 2026

Infection-associated lipopolysaccharide aggravates doxorubicin-induced cardiotoxicity via modulation of the FOXO1-GPX4 ferroptosis pathway.

Findings indicate that DOX and LPS synergistically promote myocardial injury by activating the FOXO1/GPX4-mediated ferroptosis pathway, providing mechanistic insight into infection-associated cardiotoxicity during DOX chemotherapy.

Tao Zhang, Chu-Chu Wang, Zi-Han Nan et al. · 0 citations

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