Open access
Aug 2026
Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing
Abstract Background Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. Methods We developed CDRPipe ( C omputational D rug R epurposing Pipe line), a unified framework that interr...
Enock Niyonkuru, U. Khan, Xin-Yu Tang et al.
· Research Square · 0 citations