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L. Gomez

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Open access Aug 2026

Methylation clocks fail to generalize across genetically admixed individuals

Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...

Sebastián Cruz-González, Ogechukwu Okpala, Esther Gu et al. · 0 citations
Open access Sep 2026

Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female.

BackgroundAlzheimer's disease (AD), the most common age-related neurodegenerative disease, is closely associated with both amyloid-β plaque and neuroinflammation. Two thirds of AD patients are female, and they have a higher disease risk; women with AD have more extensive brain histological changes than men along with m...

Le Zhang, Tian-Yu Liu, Chuan He et al. · 0 citations

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