Author

L. Graça

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Open access Aug 2026

Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer

Tumor-invaded lymph nodes (LNs) are critical but poorly studied hubs of anti-tumor immunity. Using single-cell transcriptome, clonotype, and chromatin profiling, we analyze CD4 + T cells from blood, LNs, and tumors of NSCLC patients. LNs and tumors are enriched in follicular regulatory T cells (Treg-Tfr), follicular-li...

Jimena Tosello Boari, W. Richer, Y. Missolo-Koussou et al. · Nature Communications · 0 citations

Aug 2026

Adenosine 2A receptor drives microglial efferocytosis to accelerate white matter repair and functional recovery after stroke.

Although reperfusion therapy effectively restores blood flow to occluded brain arteries after ischemic stroke, many patients develop persistent white matter injury, a major contributor to long-term neurological disability. Currently, there are few approved clinical therapies that specifically target white matter repair...

Yanfang Deng, Qian He, Bolin Yao et al. · Science Signaling · 0 citations