Author

L. Gragnani

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Review Open access Aug 2026

From Antigenic Drive to Clonal Autonomy: An Update on Molecular Mechanisms of HCV-Related B-Cell Lymphomagenesis

Simple Summary Chronic hepatitis C virus (HCV) infection is a well-established risk factor for B-cell non-Hodgkin lymphoma and represents one of the best models of infection-driven cancer development. Although the introduction of antiviral therapies has markedly reduced the burden of hepatitis C, lymphomas continue to...

Silvia Marri, M. Scavuzzo, G. Cavallini et al. · Cancers · 0 citations

Open access Aug 2026

Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer.

KDM2A acts as a key epigenetic regulator of mitochondrial function, genomic stability, and the tumor immune microenvironment in liver cancer, and may enhance tumor immunogenicity and improve responses to immunotherapy, representing a promising therapeutic strategy.

L. Gragnani, M. Lulli, Patrizio Caini et al. · British Journal of Cancer · 0 citations

Review Open access 2026

Cancer-Associated Fibroblasts-Orchestrated Immune Remodeling as a Key Driver in Liver Cancer

Overall, CAFs are central orchestrators of immune remodeling in liver cancer and contribute to the establishment of an immunosuppressive microenvironment that supports tumor progression and therapeutic resistance.

N. Porro, Silvia Marri, F. Salani et al. · Oncology Research · 0 citations