Frontotemporal lobar degeneration (FTLD), predominantly comprised of tau and TDP-43 proteinopathies, is a common cause of early-onset dementia. Biomarkers that reliably classify FTLD subtypes are limited, thereby hindering in-vivo diagnosis and clinical trial stratification. We conducted large-scale, multi-platform cer...
R. Saloner, L. Cornelis, Joshua Downer et al.· bioRxiv· 0 citations
By replacing empirical, from-scratch architectures with a generalizable foundation model adapter framework, ViTamyloid provides a highly sensitive scalable digital pathomics toolkit, offering objective, quantitative endpoints for Alzheimer's disease clinical trials and disease subtyping.
Y. Chen, B. D. Boon, E. Engelberg-Cook et al.· medRxiv· 0 citations
Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non‐rapid eye movement (NREM) sleep, but its disease‐specific vulnerability is unclear.
Shima Rastegar-Pouyani, Caroline Lew, F. Pereira et al.· Alzheimer's & Dementia· 0 citations
BACKGROUND
Lewy body disease (LBD) is defined by neuronal α-synuclein pathology, but how Braak-staged LBD relates to mixed neuropathology and clinical manifestations within a single population-based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which...
Vitor Ribeiro Paes, Felipe L. Pereira, C. M. Silva et al.· Movement Disorders· 0 citations
Abstract Sleep disturbances are frequently observed in patients with neurodegenerative diseases, but in vivo evidence linking subcortical sleep–wake structures to sleep phenotypes is limited. We aim to examine associations between MRI-derived measures of subcortical sleep–wake regulating regions and polysomnographic sl...
A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...
L. Grinberg, M. Murray· Nature Reviews Neurology· 0 citations
It is found that engraftment of wild-type, but not Grn-deficient, human microglia restore brain-wide progranulin levels, normalize microglial transcriptional states, and ameliorate pathological, functional, and behavioral phenotypes associated with progranulin loss.
H. Davtyan, Sarah Naguib, Y. Voskobiynyk et al.· Molecular Neurodegeneration· 0 citations
Preliminary evidence of the relationship between subjective sleep preferences and objective circadian data in cognitively healthy older adults with notable sex differences in these relationships is provided.
Natalie S. Pandher, L. Yack, E. Li et al.· PLoS ONE· 0 citations
Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.
S. R. Dunlop, Sarah J. Lincoln, Zhongwei Peng et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
