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Open access Oct 2026

Multimodal modeling of the ictal onset zone in refractory insular epilepsy and seizure outcome of magnetic resonance-guided laser interstitial therapy: A pediatric single-center retrospective study.

OBJECTIVE This study was undertaken to evaluate seizure outcomes after magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) in children with insular epilepsy and to assess how the extent of ablation overlaps with multimodal definitions of the ictal onset zone (IOZ). METHODS We conducted a retrospect...

L. Guida, E. Losito, Sebastian Rodrigo et al. · 0 citations
Open access Oct 2026

Real-life efficacy and tolerance of trametinib in BRAF-rearranged low-grade gliomas: A multicenter study.

BACKGROUND MEK inhibition has demonstrated activity in pediatric low-grade gliomas (pLGGs) driven by BRAF rearrangements, but data on trametinib remain limited, regarding efficacy, short and long-term toxicities. METHODS We conducted a retrospective multicenter study of patients with BRAF-rearranged non NF1 pLGGs rec...

Céline Khouri, Amandine Bibollet, Y. Bouchoucha et al. · 0 citations

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