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Open access Sep 2026

Perioperative transcutaneous auricular vagus nerve stimulation for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: protocol for a randomized, double-blind, sham-controlled trial

BackgroundPostoperative nausea and vomiting (PONV) remains a common and distressing complication after gynecologic laparoscopic surgery, despite the use of multimodal antiemetic prophylaxis. Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive neuromodulation technique that targets vagal afferents...

R. Wang, H. Yang, H. Li et al. · 0 citations
Open access Sep 2026

GC801-enabled AAV gene therapy in a neonate with Pompe disease

We report a neonate with IOPD who had high pre-existing anti-AAV9 antibody titers, which precluded eligibility for AAV9-mediated gene therapy (GC301). Preconditioning with a single dose of the IgG-degrading enzyme GC801 (0.2 mg/kg) safely reduced serum IgG from 6.25 g/L to a nadir of 0.72 g/L within 5 days. This pharma...

J. Chen, W. Ma, H. Qi et al. · 0 citations

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