Author

L. Hughes

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Open access Jul 2026

Functional assessment improves discrimination of clinical and biomarker-defined Alzheimers disease

In a contemporary, diverse cohort, most established dementia risk algorithms had limited power in discriminating amyloid positivity, pTau-217 positivity, and current cognitive status despite acceptable calibration.

K. Mavromati, A. Dibble, L. Tvrdá et al. · medRxiv · 0 citations

Open access Aug 2026

Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimers disease spectrum

A multivariate blood-based framework integrating 19 molecular assays and six risk instruments in the Bio-Hermes-001 cohort supports resilience and resistance as molecularly distinct subgroups and provides a scalable framework for pathology-informed stratification and mechanistic investigation.

K. Mavromati, C. Dalby, A. Dibble et al. · medRxiv · 0 citations