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Author

L. J. Jensen

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Open access Aug 2026

Systematic evaluation of the heterogeneity of topologically associating domain boundaries in a large genomic context in humans

Abstract Topologically associating domains (TADs) are generally considered as a homogeneous basic units of genome folding, which is critical for transcriptional regulation. However, recent studies indicate that both the TAD domain structures and the boundaries between them are not as homogeneous as originally recognize...

Ying Sun, Niels Tommerup, L. J. Jensen et al. · 1 citation
Open access Sep 2026

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

A single-nucleus transcriptomic atlas spanning the human lifespan is used to show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in la...

Hui Yang, Tereza Clarence, Madeline R. Scott et al. · 4 citations
Open access Aug 2026

SLIM: A small linear model with STRING embeddings for single-cell genetic perturbation prediction

The results show that compact biological representations can support accurate and computationally efficient perturbation prediction, and highlight the importance of perturbation representations and population-construction procedures in low-data benchmarks.

Dewei Hu, Marc Pielies Avellí, L. J. Jensen et al. · 0 citations

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