Author

L. Kahl

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Open access Sep 2026

Fitness costs of antibiotic resistance mutations in rich media do not reliably predict those in infection-like environments

The acquisition of antibiotic resistance is typically associated with a fitness cost, reducing the competitive ability of cells in the absence of antibiotics. Our ability to predict these costs informs our ability to predict how likely it is that resistance will subside in the absence of treatment. Fitness costs are ty...

Jack Knowles, Lauren M. Pittaccio, Selina Lindon et al. · bioRxiv · 0 citations

Jul 2026

Metabolic adaptation enabling D-xylose assimilation via the Entner-Doudoroff pathway in glycolysis-impaired Escherichia coli strains.

This study revealed that mutations in key enzymes and transcriptional regulators at various metabolic branching points were essential for effective growth on D-xylose, enabling optimized partitioning of carbon through central metabolism despite the loss of the canonical EMP glycolytic route.

C. Iacometti, Valérie A. Delmas, Mélodie Cadillon et al. · Metabolic Engineering · 0 citations