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Author

L. Kilpatrick

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Open access Oct 2026

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

ABSTRACT Resistance of lung cancer to EGFR‐targeting tyrosine kinase inhibitors (TKIs) like osimertinib frequently results from secondary mutations or activation of bypass signaling pathways. Re‐analysis of clinical data unveiled elevated expression of GAS6 and its receptor MERTK in lung cancer patients developing resi...

Suvendu Giri, Boobash-Raj Selvadurai, Nitin Gupta et al. · 0 citations
Open access Aug 2026

Discovery of uracil-based antagonists and fluorescent ligands of the P2Y2 receptor.

Through a fragment recombination approach utilizing P2Y2R privileged fragments to explore non-additive SAR trends in combination with molecular docking studies, a series of potent uracil-based P2Y2R antagonists are discovered, such as compound 26a.

Mahesh Puthanveedu, Natasha C. Dale, Rebecca Knight et al. · 0 citations

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