Author

L. Lei

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Open access Sep 2026

LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation

Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5+ mechanically induced regulatory fibroblasts (LGR5+ MIRFs) in mouse and human dermis, whose induction requires a YAP/AP-1-dependent transcriptional program. LGR5+ MIRFs channel mechanic...

Qiao-Yu Fu, Xi Cheng, Nuo Chen et al. · Nature Communications · 0 citations

Open access Jul 2026

Metabolomic signatures for diagnosis and clinical severity in Parkinson's disease

Findings indicate reproducible plasma metabolic differences associated with early PD and suggest the potential diagnostic value of internally validated classifiers for disease diagnosis, and suggest the need for further mechanistic and translational research.

Yige Wang, Ya-Qin Xiang, Xiurong Huang et al. · EBioMedicine · 2 citations