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Author

L. López-Kleine

3 papers indexed here

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Open access Sep 2026

H3K9ac promoter profiling and their association with gene expression in immune cells of T2-high asthma patients.

BACKGROUND Asthma is a heterogeneous chronic inflammatory syndrome, with the T2-high endotype defined by robust type 2 immune responses and skewed T helper polarization. Although H3K9 acetylation (H3K9ac) is a key activating histone mark in T helper differentiation, its genome-wide promoter landscape in circulating imm...

Daniel González, Alexis Infante, L. López-Kleine et al. · 0 citations
Open access Sep 2026

Co-expression of the Mammaglobin (SCGB2A2) Gene With hsa-miR-184 and hsa-miR-190b Indicates Its Possible Role in Oncogenic Pathways in Breast Cancer

A positive correlation among the expression of hsa-miR-184, hsa-miR-190b, and SCGB2A2 suggests that they may participate in shared biological pathways that govern critical cellular processes, such as membrane trafficking and cell signaling, which are frequently disrupted in cancer.

Juan Felipe Abella-Duque, L. López-Kleine, R. Parra-Medina et al. · 0 citations
Review Aug 2026

EXPRESS: Harnessing Single-Cell Gene Regulatory Networks for Precision Health.

This manuscript explores the current landscape of single-cell RNA sequencing (scRNA-seq), highlighting key studies that have leveraged this technology to advance biological understanding for clinical purposes through the construction of gene regulatory networks (GRNs) from single-cell transcriptomic data.

J. López-Castiblanco, L. López-Kleine, Yesid Cuesta-Astroz · 0 citations

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