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Review Open access Aug 2026

Juvenile Parkinson's disease: Symptom burden and treatment challenges

Juvenile Parkinson's disease (JPD) is a rare condition characterized by the onset of parkinsonian motor symptoms before the age of 21. Sixteen patients with JPD who presented to the Mayo Clinic between 1990-2020 were included. The median age of symptoms onset was 18.5 years, and six cases had pathogenic PRKN mutations....

L. Malfer, Capucine Piat, Aidan F. Mullan et al. · 0 citations
Open access Aug 2026

Cumulative incidence and risk factors of dementia in Parkinson's disease and parkinsonism: a population-based study

Abstract Cognitive impairment is among the most common non-motor symptoms in parkinsonism and Parkinson’s disease, ranging from subjective complaints to dementia. Although several predictive factors have been described, their prognostic relevance remains uncertain. This study aimed to examine the predictive association...

L. Malfer, Aidan F. Mullan, Elena Lynott et al. · 0 citations

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