Development and multi-dataset evaluation of a unified single-view deep-learning model for the right heart: four-chamber segmentation, biventricular ejection fraction, deformation, and pulmonary-hypertension prediction from the apical four-chamber echocardiogram
Background: Right ventricular (RV) function predicts survival in pulmonary hypertension (PH) and other cardiovascular diseases, yet echocardiographic AI has largely focused on the left ventricle (LV). Objectives: To develop and evaluate PH-ECHO-AI, a unified deep learning model performing four-chamber segmentation, landmark localisation, biventricular ejection fraction (EF) estimation, deformation analysis, and PH prediction from a single apical four-chamber (A4C) clip. Methods: We developed the model using 8,416 clips from four public datasets and no institutional data: EchoNet-Dynamic, CAMUS, RVENet (apical four-chamber clips paired with 3D-echocardiographic right ventricular ejection fraction, RVEF), and MIMIC-IV-ECHO. Evaluation used held-out, training-excluded data with expert-reviewed reference standards and a per-cohort audit of patient-level separation: 1,416 clips for segmentation; 600 clips for function and deformation (350 referenced to 3D-echocardiographic RVEF, 250 to the EchoNet LVEF); and 1,076 MIMIC-IV patients for PH prediction, with five-fold cross-validation. Performance measures were Dice, correlation, mean absolute error (MAE), Bland-Altman agreement, and area under the receiver operating characteristic curve (AUC). Results: Four-chamber segmentation generalised robustly across all datasets (pooled Dice: LV 0.925, RV 0.836, LA 0.910, RA 0.904). Left ventricular ejection fraction (LVEF) was estimated with r=0.845 (95% CI 0.786 to 0.886) and MAE 4.67%. RVEF, regressed directly from the clip by a supervised head trained on 3D-echocardiographic labels with no geometric assumption, reached r=0.754 (95% CI 0.690 to 0.806) and MAE 4.98%, matching published single-view RVEF ceilings and exceeding geometric RV fractional area change (RVFAC; r=0.278). Deformation and excursion metrics, namely RV free-wall and LV A4C longitudinal strain and tricuspid and mitral annular plane systolic excursion (TAPSE, MAPSE), proved physiologically coherent. Segmentation generalised to the external MIMIC-IV cohort, and PH prediction was developed and evaluated entirely within it; RVEF evaluation was clip-disjoint and same-source, so cross-centre RVEF validation remains outstanding. Using echocardiographic geometry alone, confirmed PH was detected with an AUC of 0.697 and strong calibration (Brier 0.061). Conclusions: A single, reproducible model provides comprehensive right-heart-focused interpretation from one A4C view. It achieves RVEF accuracy competitive with dedicated RV models while simultaneously delivering segmentation, deformation, annular excursion (TAPSE and MAPSE), and PH prediction. Registration: This retrospective study used existing datasets. Code is openly released, and trained model weights are available to credentialed investigators, for independent evaluation.