Circulating metabolic correlates of depressive symptoms are heterogeneous and strongly dependent on symptom phenotype and BMI-related metabolic context, suggesting that metabolic biomarkers in depression should be interpreted in relation to both symptom presentation and metabolic state rather than as uniform correlates...
S. Kurvits, N. Taba, Estonian biobank research team et al.· medRxiv· 0 citations
BACKGROUND AND AIMS
Up to half of patients switch or discontinue antihypertensive medications within the first year, but underlying mechanisms remain elusive. This study aimed to identify genetic predictors of antihypertensive medication use trajectories within the first year.
METHODS
Using longitudinal medication da...
F. Vaura, Kristi Krebs, T. Kiiskinen et al.· European Heart Journal· 0 citations
The results underscore the role of psychiatric genetic liability, beyond diagnosed psychiatric disorders, in contributing to both COVID-19 and other respiratory infection severity, and provide insights that may improve future risk stratification and public health strategies targeting respiratory viruses.
K. Kõiv, R. Askeland, L. N. Christoffersen et al.· Genome Medicine· 0 citations
This work developed a neural network model, nnCNV, to predict deletions in the CYP2C19 pharmacogene region from array intensity signals and demonstrated that long-range information, which cannot be utilized by hidden Markov models, can improve CNV calling.
Burak Yelmen, R. Hofmeister, Viido Kaur Lutsar et al.· bioRxiv· 0 citations
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