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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

L. Milles

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Open access Oct 2026

Joint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models

Protein design typically generates amino acid sequences first and then translates them into DNA post-hoc limiting control over the nucleotide sequence via codon choice at design time. We introduce NuCaliby, a structure-conditioned model that jointly designs amino acid, mRNA, and DNA sequences of a protein at nucleotide...

Błażej Banaszewski, Lars J. Dornfeld, De-Xiong Chen et al. · 0 citations
Open access Aug 2026

Intra-Protein Interfaces Control Folding Dynamics and Mechanical Stability in a De Novo Designed Repeat Protein

Together, these results show that designed repeat-protein folding is governed by seed formation, interface propagation, and terminal boundary conditions, and establish intramolecular crosslinking as a strategy for rationally reshaping folding landscapes in designed proteins.

Melanie Weiß, Anna Lisa Heit, L. Milles et al. · 0 citations

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