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Open access Sep 2026

Inotropic effects of 3-hydroxybutyrate in a rodent heart: pressure-volume and isolated rat ventricular trabeculae analysis

An administration of 3 hydroxy-butyrate (3-OHB) in experimental animals or humans is associated with an increase of cardiac output (CO), but whether this hemodynamic benefit reflects direct myocardial inotropy or heart unloading due to peripheral vasodilation remains unclear. It is also unknown if myocardial effects ar...

J. Kropáček, Thu Thao Nguyen, Ema Hájková et al. · 0 citations
Open access Sep 2026

Persistent C-reactive protein elevation and incident heart failure in adults at increased cardiovascular risk: A multinational electronic health record study.

BACKGROUND Systemic inflammation has been associated with heart failure (HF) development. C-reactive protein (CRP) is a sensitive marker of inflammation, but its prognostic association with incident HF remains incompletely defined. We explored whether persistent CRP elevation was associated with incident HF among adult...

M. Busti, L. Monzo, T. Rastogi et al. · 0 citations
Open access Aug 2026

Left atrial remodeling and functional maladaptations in obesity: an invasive pressure-volume analysis

In patients undergoing AF ablation, higher BMI is associated with a predominantly load-related pattern of LA remodeling, characterized by larger LA volume and pressures, greater cyclic wall stress, and a rightward shift of the estimated pressure–volume relationship.

L. Monzo, B. Borlaug, K. Kroupova et al. · 0 citations

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