Author

L. O. Soto-Rojas

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Review Open access Oct 2026

“Morphological, Functional, and Molecular Progression of Blood-Brain Barrier Dysfunction in Alzheimer’s Disease”

Blood-brain barrier (BBB) dysfunction is increasingly recognized as an early pathological event in sporadic Alzheimer’s disease (AD), which represents over 95% of cases. Vascular risk factors and cerebral insulin resistance are considered potential contributors to its initiation. This review synthesizes evidence availa...

Karen León-Arcia, Humberto Martínez-Orozco, Magdalena Guerra-Crespo et al. · Journal of Molecular Neurosc... · 0 citations

Open access Sep 2026

Obesity and COVID-19 severity independently shape adipokine dysregulation and immune cell remodeling

Background Obesity is a major risk factor for severe COVID-19, yet the immunological mechanisms by which it modifies disease progression remain incompletely characterized. We aimed to dissect the independent and interactive contributions of obesity and COVID-19 severity on circulating adipokines, cytokines, and immune...

Karla Jimena Basilio-Aguilar, Alfredo Pérez-Fragoso, Edith Cerón-Cruz et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Mitochondrial resilience: a convergent framework for pathogenesis and neuroprotection in Parkinson’s disease

This integrated framework reframes PD as a disorder of impaired cellular maintenance rather than solely a consequence of late-stage degenerative processes, and provides a translational shift from mechanism-based biomarkers to early detection of mitochondrial failure and supports therapeutic strategies aimed at restorin...

Oscar Arias-Carrión, Magdalena Guerra-Crespo, L. O. Soto-Rojas et al. · Frontiers in Pharmacology · 0 citations