Author

L. Paeger

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Open access Sep 2026

Axonal Branch Points of Parvalbumin Interneurons are Focal Sites of Tau-Induced Degeneration

Tau aggregation, a defining feature of tauopathies, commonly appears as neuropil threads within neurites including axons. However, the affected neuronal populations and the spatial organization of axonal vulnerability remain poorly defined. Here, following identification of Tau accumulation in parvalbumin (PV) interneu...

Paul L. C. Feyen, Yu-Xiao Zhang, Theresa Niedermeier et al. · bioRxiv · 0 citations

Open access Aug 2026

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

A reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and enabling the study of Alzheimer’s disease-relevant perturbations and drug responses is developed.

Julien Klimmt, Carolina Cardoso Gonçalves, J. V. Montgomery et al. · Nature Neuroscience · 1 citation