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Author

L. Petrosini

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Open access Jul 2026

Stage-dependent effects of cognitive reserve on memory and brain structural integrity across the spectrum from healthy aging to Alzheimer’s disease

Findings support a stage-dependent model of CR, characterized by an additive protective role in healthy aging, patterns consistent with compensatory recruitment in early cognitive decline, and a possible loss of reserve effectiveness beyond a critical neuropathological threshold.

Laura Serra, Sabrina Bonarota, Giulia Caruso et al. · 0 citations

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