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Author

L. Quek

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Open access Sep 2026

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis.

Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have been linked to inflammatory phenotypes and...

Maroof Hasan, Sylvia Durandeau, I. R. Thompson et al. · 0 citations
Sep 2026

SLIT2 modulates leukaemic cell proliferation and stromal support in acute myeloid leukaemia models.

Acute myeloid leukaemia (AML) is supported by leukaemic stem cells (LSCs), whose continued existence and growth are dependent upon signals derived from their bone marrow (BM) microenvironment. Although the highly conserved glycoprotein slit guidance ligand 2 (SLIT2), implicated in axon guidance, has been proposed to su...

Luise Albuquerque-Simões, I. Weinhäuser, D. Pereira-Martins et al. · 0 citations

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