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Author

L. Oliveira

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Open access Oct 2026

Rational design of a consensus bothropic metalloproteinase as an immunogen for broadly protective antivenom development.

Antivenoms remain the only specific therapy for snakebite envenoming. In Bothrops venoms, Snake Venom Metalloproteinases (SVMPs) are abundant and highly diverse toxins responsible for the major local and hemotoxic effects induced by envenoming. However, currently available bothropic antivenoms fail to fully neutralize...

Ramon de Oliveira Souza, Júlia Helena de Souza Santos, Raphaella Oppenheimer de Toledo et al. · 0 citations
Open access Aug 2026

Beyond the full-length toxin: The metalloprotease domain of Pictolysin-III retains key functional properties and cellular activity.

It is demonstrated that the metalloprotease domain constitutes an active functional unit of Pictolysin-III, with rMD-Pp more closely reproducing the functional properties of the native toxin than rMD-Ec, however, the two recombinant preparations differed in their biochemical and biological profiles.

A. Roque, D. Torrejón, Alex Proleón et al. · 0 citations

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