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Open access Aug 2026

New Insights into Binding of G-segment DNA to the Active Site of Escherichia coli Topoisomerase III

Escherichia coli topoisomerase III (EcTopo3) is a type IA topoisomerase that binds single-stranded DNA (ssDNA) during DNA cleavage and strand passage. Here, we report five crystal structures of EcTopo3 in complex with distinct 8-base ssDNA oligonucleotides at 1.85–2.22 Å resolution. These structures reveal a previously...

Ke-Min Tan, T. Annamalai, L. Stols et al. · 0 citations

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