From Proteinopathy to Immunopathy in Alzheimer's Disease—A Role for Astrocytic Calcineurin?
The contemporary version of the most widely accepted model of Alzheimer's disease (AD), the β-amyloid cascade hypothesis, identifies β-amyloid oligomers as the primary neurotoxic species. Arising either from genetic mutations or environmental and lifestyle predisposing factors (collectively termed the ex-posome), β-amy...