Spatial transcriptomics extends single-cell analysis of the tumor microenvironment into a mappable ecosystem by resolving gene expression in situ. Within it, cells assemble into recurrent multicellular niches whose spatial organization shapes tumor progression, immune evasion, and therapy response and resistance. Yet...
Álvaro Curiel-García, M. Franchini, L. Tomassoni et al.· Cancer Research· 0 citations
Oncogenic KRAS mutations are present in ∼95% of pancreatic ductal adenocarcinoma (PDAC) cases and have long been considered undruggable. The recent clinical emergence of RAS inhibitors marks a transformative moment in PDAC therapy, yet their impact on the tumor microenvironment (TME) remains largely unknown. This is...
Marie C. Hasselluhn, Allison C. Hess, L. Tomassoni et al.· Cancer Research· 0 citations
A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 7 citations
The authors apply ARACNe and metaVIPER to published scRNA-seq datasets to characterize pancreatic cancer subtypes, identifying six distinct cell states as well as their mechanistic determinants.
P. Laise, Mikko M. Turunen, Álvaro Curiel-García et al.· Nature Genetics· 1 citation
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