Highlights • Mpox seroprevalence was 5.5% in a high-risk cohort of people living with human immunodeficiency virus in Bangkok during 2022.• Seropositivity was detected as early as January 2022, predating clinical reports.• Findings suggest unrecognized transmission occurred months before the official outbreak.• Illicit...
E. Co, Paramate Promnarate, M. Imbach et al.· IJID Regions· 0 citations
It is found that the accumulation of mutations was slower than expected, implying a selection against HIV-1 diversification in acute infection, potentially leaving a window of low genetic diversity for the study of new interventions towards inducing viremic control, such as immunotherapy or mRNA vaccination.
A. Capoferri, V. Boltz, W. Shao et al.· bioRxiv· 0 citations
A dynamic CD8+ T cell state continuum is identified as a central determinant of HIV-1 rebound, even in the absence of antigen-specificity, where ART establishes a predictive poised naïve state that can be further leveraged by vaccination to enhance protective stem-like memory responses.
Jie Wang, Gautam Kundu, P. Ehrenberg et al.· bioRxiv· 0 citations
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