Open access
Aug 2026
Human cortico-vascular assembloids reveal a CELF2-AHNAK-dependent switch from neuronal to endothelial tropism in glioblastoma cells
CO + EO assembloids are established as an original human model of GBM plasticity at the neurovascular interface and identify CELF2 as a master regulator of GSC tropism and AHNAK as a mediator of vascular affinity, revealing a molecular axis that governs GBM invasion and providing potential avenues for future therapeutic intervention.
Michele Bertacchi, A. Ladoux, A. Saliou et al.
· Cell Death & Disease · 0 citations